Oral drug strip development[ edit ] Strip forming polymers[ edit ] The polymer employed should be non-toxic, non-irritant and devoid of leachable impurities.

Formulation and evaluation of fast dissolving films of levocitirizine di hydrochloride

It should have good wetting and spreadability property. The polymer should exhibit sufficient peel, shear and tensile strengths. The polymer should be readily available and should not be very expensive. Film obtained should be tough enough so that there won’t be any damage while handling or during transportation. Combination of microcrystalline cellulose and maltodextrin has been used to formulate Oral Strips of piroxicam made by hot melt extrusion technique.

Pullulan has been the most widely used film former used in Listerine PocketPak, Benadryl, etc.

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Plasticizers[ edit ] Plasticizer is a vital ingredient of the OS formulation. It helps to improve the flexibility of the strip and reduces the brittleness of the curriculum vitae upper or lowercase properties by reducing the glass transition temperature of the polymer.

GlycerolPropylene glycollow molecular weight polyethylene glycolsphthalate derivatives buccal fast dissolving film thesis dimethyldiethyl and dibutyl phthalateCitrate derivatives such as tributyl, triethyl, acetyl citrate, triacetin and castor oil are some of the commonly used plasticizer excipients. Active pharmaceutical ingredient[ edit ] Since the size of the dosage form has limitation, high-dose molecules are difficult to be incorporated in OS.

The sweet taste in formulation is more important in case of pediatric population.

Development of polymer-bound fast-dissolving metformin buccal film with disintegrants

Natural sweeteners as well as artificial sweeteners are used to improve the flavor of the mouth dissolving formulations for the flavors changes from individual to individual. Pigments such as titanium dioxide is incorporated for coloring. Stabilizing and thickening agents[ edit ] The stabilizing and thickening agents are buccal fast dissolving film thesis to improve the viscosity and consistency of dispersion or solution of the strip preparation solution or suspension buccal fast dissolving film thesis casting.

Drug content uniformity is a requirement for all dosage forms, particularly those containing low dose highly potent drugs. To uniquely meet this requirement, thin film formulations contain buccal fast dissolving film thesis dispersions of drug throughout the whole manufacturing process. Montelukast indicated for the treatment of asthma and allergy, is being developed for use as a film by Monosol Rx. Midatech, a company specializing in nanotechnology, is partnering with Monosol Rx to create a film-based insulin.

Rizatriptan indicated for the treatment of migraine, is being developed for use ba thesis english phase 1. Undergraduate biomedical engineering students at Johns Hopkins University have created a new drug delivery system based on the thin-film technology used by a breath freshener.

Laced with a vaccine against rotavirusthe strips could be used to provide the vaccine to infants in impoverished areas.

Overview and future potential». Journal of Controlled Release. Hariharan, Madhu; Bogue, B.

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(нет рейтинга)

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